北柴胡 (Bupleurum chinense DC .)茎叶总黄酮 (TFB) 0.09g kg剂量组对乙型流感病毒 (B /京防 98-76 )感染小鼠具有明显的保护作用 (P <0 .0 5 ) ,0.03g kg和0.09g kg剂量组能明显降低乙型流感病毒 (B /京防 98-76 )感染小鼠肺指数值 (P <0 .0 5 ,P <0 .0 1) ,肺指数抑制率分别为 2 0 .5 %和 2 5 .4 %。组织病理学检查结果表明 ,TFB各剂量组与模型组比较 ,肺部病变均明显减轻 ,其中以TFB高剂量组肺部总体病变程度最轻 ,疗效最好。

Total flavonoid from the aerial part of Bupleurum chinense DC .(TFB)evidently has an inhibitory
effect on influenza virus .The 0 .09 g /kg group has an obvious protection to infected mice by the influenza B virus (B jingfan 98-76)(P <0 .05).The 0 .03 g /kg and 0 .09 g /kg groups could remarkablely reduce the value of lung index of infected mice, the inhibitory rates of which are 20 .5 % and 25 .4 % respectively (P <0 .05 and P <0 .01).The results of histopathological observation show that , comparing with the model groups , the lung pathological processes of the infected mice all were remarkablely relieved in all of the dosage groups of the total flavonoid , among which the curative effect of the high dosage group (0 .09 g /kg)is the most
evident .