2024年7月23日 星期二
北柴胡茎叶总黄酮抗流感病毒的作用
Effects of total flavonoid from the aerial part of Bupleurum chinense DC. on infected mice by influenza virus
2002年 第11卷 第4期 页码[15-18]    下载全文[6.2MB]  
摘要

北柴胡 (Bupleurum chinense DC .)茎叶总黄酮 (TFB) 0.09g kg剂量组对乙型流感病毒 (B /京防 98-76 )感染小鼠具有明显的保护作用 (P <0 .0 5 ) ,0.03g kg和0.09g kg剂量组能明显降低乙型流感病毒 (B /京防 98-76 )感染小鼠肺指数值 (P <0 .0 5 ,P <0 .0 1) ,肺指数抑制率分别为 2 0 .5 %和 2 5 .4 %。组织病理学检查结果表明 ,TFB各剂量组与模型组比较 ,肺部病变均明显减轻 ,其中以TFB高剂量组肺部总体病变程度最轻 ,疗效最好。

Abstract

Total flavonoid from the aerial part of Bupleurum chinense DC .(TFB)evidently has an inhibitory
effect on influenza virus
.The 0 .09 g /kg group has an obvious protection to infected mice by the influenza B virus (B jingfan 98-76)(P <0 .05).The 0 .03 g /kg and 0 .09 g /kg groups could remarkablely reduce the value of lung index of infected mice, the inhibitory rates of which are 20 .5 % and 25 .4 % respectively (P <0 .05 and P <0 .01).The results of histopathological observation show that , comparing with the model groups , the lung pathological processes of the infected mice all were remarkablely relieved in all of the dosage groups of the total flavonoid , among which the curative effect of the high dosage group (0 .09 g /kg)is the most
evident
.
 

关键词北柴胡茎叶; 总黄酮; 乙型流感病毒;
Key wordsthe aerial part of Bupleurum chinense DC.; total flavonoid; influenza B virus
作者冯 煦 , 王 鸣 , 赵友谊 , 单 宇 , 董云发
所在单位江苏省中国科学院植物研究所 江苏省药用植物研究中心, 江苏 南京210014
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下载次数935
基金项目江苏省应用基础研究基金资助项目(BJ000035)