2025年8月1日 星期五
西南绣球茎和根乙醇提取物中的三萜类成分及其体外抗疟活性
Triterpenoids in ethanol extract from stems and roots of Hydrangea davidii and their in vitro antimalarial activity
2025年 第34卷 第4期 页码[113-116]    下载全文[0.9MB]  
摘要

为了探究西南绣球(Hydrangea davidii Franch.)在抗疟药物方面的应用价值,对西南绣球茎和根乙醇提取物中石油醚萃取部分的化学成分进行了分离鉴定和体外抗疟活性检测。结果表明:共分离鉴定出10个三萜类化合物,分别为α-香树脂醇(1)、熊果醛(2)、熊果酸(3)、乙酰熊果酸(4)、28-norurs-12-ene-3β-ol(5)、28-norurs-12-ene-3β,17β-diol(6)、海棠果醇(7)、木栓酮(8)、3-表木栓醇(9)、3β-hydroxyglutin-5-ene(10)。以上化合物均首次从西南绣球中分离获得,并且化合物1、2、4~7、10首次从绣球属(Hydrangea Linn.)中分离获得。体外抗疟活性检测结果显示化合物2、4、6和8的抗疟活性较强。

 

Abstract

 In order to explore the application value of Hydrangea davidii Franch. in antimalarial drugs, the chemical components in petroleum ether extract fraction from ethanol extract of stems and roots of H. davidii were isolated and identified, and their in vitro antimalarial activities were detected. The results show that a total of ten triterpenoids were isolated and identified, namely α-amyrin (1), ursolic aldehyde (2), ursolic acid (3), acetylursolic acid (4), 28-norurs-12-ene-3β-ol (5), 28norurs-12-ene-3β, 17β-diol (6), canophyllol (7), friedelin (8), 3-epifriedelinol (9), and 3β-hydroxyglutin-5-ene (10). These compounds are isolated from H. davidii for the first time, and compounds 1, 2, 4-7, and 10 are isolated from Hydrangea Linn. for the first time. In vitro antimalarial activity test result shows that compounds 2, 4, 6, and 8 have strong antimalarial activity.

 

关键词西南绣球; 三萜类; 结构鉴定; 体外抗疟活性
Key wordsHydrangea davidii Franch.; triterpenoids; structure identification; in vitro antimalarial activity
作者王静a,b,c, 祖维娟a,b,c,何龙飞a,b,c, 李港a,b,c, 姜北a,b,c, 肖朝江a,b,c
所在单位大理大学: a. 云南省滇西抗病原植物资源筛选研究重点实验室, b. 药物研究所, c. 药学院, 云南 大理 671013
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基金项目国家自然科学基金项目(82460689); 云南省基础研究计划面上项目(202201AT070005); 云南省高层次科技人才及创新团队选拔专项-中青年学术和技术带头人后备人才项目(202405AC350025); 云南省专家工作站项目(202405AF140029)