2024年7月18日 星期四
竹叶椒抑制血小板活化因子(PAF)的活性成分
The active constituents of platelet-activating factor (PAF) inhibitors from Zanthoxylum planispinum Sieb. et Zucc.
1993年 第2卷 第2期 页码[25-27]    下载全文[0.3MB]  
摘要

自芸香科花椒属植物竹叶椒(Zanthoxylum planispinum Sieb.et Zucc)根和茎的石油醚及二氯甲烷提取物中分离得到5个化合物(I~V),经物理常数测定,光谱(UV,IR,HNMR,MS)分析分别鉴定,Ⅰ为β-香木脂醇,Ⅱ为β-谷甾醇,Ⅲ为L-细辛脂素,Ⅳ为L-竹叶椒脂素,V为花椒明碱。其中Ⅲ,IV,V具有抑制PAF聚集的活性,以Ⅳ活性最强,Ⅲ次之,V较弱。花椒明碱首次从该植物中分离得到。

Abstract

Five compounds were isolated from the petroleum ether and methylene chloride extracts of the roots and stems of Zanthoxylum planispinum (Rutaceae). The structure of these compounds were determined on the basis of physical constant and UV, IR, 1HNMR, MS spectral analysis. They are β-amyrin ( I ), β-sitosterol ( II ), L-asarinin (Ⅲ ) , L-planinin ( IV ) and zanthobungeanine ( V ) respectively. Compound Ⅲ , IV , V showed obviously inhibitoryactivity to platelet aggregation caused by PAF, among them compound Ⅲ was less active than compound IV , compound V was the least. Zanthobungeanine was isolated for the first time from this plant.

 

关键词竹叶椒; L-竹叶椒脂素; PAF;
Key wordsZanthoxylum planispinum Sieb. et Zucc.; L-planinin; PAF
作者洪美芳,潘竞先, 郝美荣 ,姚冰,韩桂秋
所在单位南 京 中医 学 院 , 南京 2 1 0 0 2 9
北 京 医科大学 药 学 院 , 北 京 1 0 0 0 8 3
点击量1102
下载次数727
基金项目天然药物及仿生药物国家重点实验室资助课题;