2024年7月21日 星期日
白背三七叶中吡咯里西啶生物碱的LC-MSn检测
Detection of pyrrolizidine alkaloids from leaf of Gynura divaricataby LC-MSn
2008年 第17卷 第2期 页码[79-80]    下载全文[0.3MB]  
Abstract

The pyrrolizidine alkaloids(PAs) in leaf of Gynura divaricata (L.) DC.was analyzed by LC-MSn technique. The result shows that two hepatotoxic pyrrolizidine alkaloids(HPAs) are detected from the methanol extract of G. divaricata leaf, with relative molecular weight of 335 and 365,respectively and lower content.The constituent with relative molecular weight 335 is a retronecine-type alkaloid, and identified as integerrimine; another constituent with relative molecular weight 365 is an otonecine-type alkaloid, speculated to be isomer of usaramine or 18-hydroxyinterrimine.

关键词白背三七; 吡咯里西啶生物碱; 全缘千里光碱; 液相色谱与多级质谱联用法(LC-MSn);
Key wordsGynura divaricata (L.)DC.; pyrrolizidine alkaloids; integerrimine; LC-MSn
作者李丽梅1,张涵庆1,吕 寒1,李维林1,徐德然2,郭巧生3
所在单位1.江苏省•中国科学院植物研究所(南京中山植物园),江苏南京210014;
2.中国药科大学中药学院,江苏南京210038;
3.南京农业大学中药材研究所,江苏南京210095
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基金项目国家自然科学基金资助项目(30470190); 南京市科学技术局现代农业项目(200501015);