2024年5月2日 星期四
枸骨的化学成分
The chemical constituents of Chinese holly ( Ilex cornuta Lindl. ex Paxt. )
2003年 第12卷 第2期 页码[1-5]    下载全文[0.7MB]  
摘要

从枸骨(Ilex cornuta Lindl. ex Paxt.)中分离得到20个化合物,鉴定了16个,分别为:枸骨甙1(Gouguside1,Ⅴ)即坡摸酸3-β-O-α-L-吡喃阿拉伯糖甙;枸骨甙2(Gouguside2,Ⅵ)即3-β-O-D-吡喃葡萄糖基坡摸酸-β-28 –O-D-吡喃葡萄糖酯;枸骨甙3(Gouguside3,Ⅶ)即3-β-O-(β-D-吡喃葡萄糖基)-α-L-吡喃葡萄糖基坡摸酸-β-28-O-D-吡喃葡萄糖酯的类似物;枸骨甙4(Gouguside4,ⅩⅦ)即3-β-O-(β-D-吡喃葡萄糖基)-α-L-吡喃葡萄糖基坡摸酸-β-28-O-D-吡喃葡萄糖酯;枸骨甙5(Gouguside5,ⅩⅧ)即坡摸酸3-β-O-α-L-2′-乙酰氧基吡喃阿拉伯糖基-28-O-β-D-吡喃葡萄糖酯,枸骨甙6(Gouguside6,ⅩⅨ)即3-β-O-(β-D-吡喃葡萄糖基)-α-L-4-乙酰氧基吡喃阿拉伯糖基坡摸酸-β-28-O-D-吡喃葡萄糖酯;枸骨甙7(Gouguside7,ⅩⅩ)即3-β-O-α-L-吡喃阿拉伯糖基-28-O-β-D-吡喃葡萄糖酯;胡萝卜甙(daucostorolⅧ);2,4 二羟基苯甲酸(2,4 dihydroxybenzoicacidⅠ);3,4 二羟基桂皮酸(3,4 dihyroxycinnamunicacidⅡ、Ⅳ);长链脂肪酸或醇5个(Longchainfattyacid,Ⅲ、Ⅵ、Ⅶ、Ⅷ、ⅩⅣ)。在鉴定的16个化合物中,枸骨甙1、枸骨甙2、枸骨甙6和枸骨甙7为首次从枸骨中分离得到,枸骨甙3和枸骨甙4为新化合物。

Abstract

Twenty compounds have been isolated from the leaves of Chinese holly ( Ilex cornuta Lindl. ex Paxt. ) , Among them, 16 compounds have been identified i. e. Gouguside 1 ( pomolic acid 3-β-O-α -Larabinopyranoside Ⅴ);Gouguside 2 〔3-β-O-D-glucopyranoside-pomolic acid ( 28 →1) -β-D-glucopyranosyl ester Ⅵ〕; Gouguside 3〔like 3-β-O-( β-D-glucopyranosyl-α -L-arabinopyranosyl) -pomolic acid( 28→1) -β-Dglucopyranosyl ester Ⅶ 〕;Gouguside 4 〔3-β-O-( β-D- glucopyranosyl-α -L-arabinopyranosyl) -pomolic acid( 28 →1) -β-D-glucopyranosyl ester ⅩⅦ 〕;Gouguside 5 (pomolic acid 3-β-O-α -L-2′ -acetoxyl- arabinopyranosyl28-O-β-D-glucopyranosyl ester, namely Cornutaside A, ⅩⅧ); Gouguside 6 〔3-β-O-( β-D-glucopyranosyl-( 1 →2) -4′ -acetoxyl-α -L-arabinopyranosyl pomolic acid ( 28→1)-β-D-glucopyranosyl ester ⅩⅨ〕; Gouguside 7 ( 3-β-O-α -L-arabinopyranosyl-pomolic acid -28-O-β-D-glucopyranosyl erter ⅩⅩ);Daucostorol (Ⅷ);2, 4dihydroxybenzoicacid (Ⅰ); 3, 4- dihyroxycinnamunic acid (Ⅱ、Ⅳ)and 5 Longchain fatty acids (Ⅲ、Ⅵ 、 Ⅶ 、Ⅷ 、ⅩⅣ)。Of which, Gouguside 1 , Gouguside 2, Gouguside 6 andGouguside 7were first isolated in I. cornuta , Gouguside 3 and Gouguside 4 are new compounds.

关键词枸骨; 三萜皂甙; 枸骨甙; 化学成分
Key wordsChinese holly; Ilex cornuta Lindl .ex Paxt .; triterpenoid saponin; gouguside; chemical
作者李维林1, 2 , 吴菊兰1 , 任冰如1 , 赵友谊1 , 张涵庆1 , 郑汉臣2
所在单位1.江 苏 省中国科学院植物研究所(南京中山植物园), 江苏 南京 210014;
2.第二军医大学药学院, 上海 200433
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