2022年11月28日 星期一
红豆杉资源与紫杉醇生产概况
A survey of Taxus resources and taxol production
1997年 第6卷 第1期 页码[48-53]    下载全文[0.8MB]  
摘要

红豆杉属(Taxus L.)植物全世界共 11 , 分布于北半球的温带至亚热带地区我国有 41 变种, :东北红豆杉(T .cuspidata Sieb.et Zucc.)、云南红豆杉(T .y unnanensis Cheng et L.K .Fu)、西藏红豆杉(T .wallichiana Zucc.)、中国红豆杉 T .chinensis (Pilger)Rehd .〕和南方红豆杉T .chinensis var.mairei (Lemee et Lévl.)Cheng et L.K.F u〕, 分布于我国大部分地区, 较为集中的产区为东北西南和华东地区云南省是我国红豆杉资源的主要分布区域红豆杉树皮中含有新型抗癌药物紫杉醇, 近年来, 由于过度砍剥致使我国红豆杉野生资源遭到严重破坏因此必须制定保护措施, 进行人工种植由于紫杉醇在红豆杉中含量甚微, 结构异常复杂, 所以研究紫杉醇的新来源成为世界性的热点, 主要研究内容包括:非树皮部分的提取, 人工大量种植 , 衍生物的寻找, 化学合成和生物技术等我国在以上研究领域内已取得多项成果, 但与世界先进国家相比还有一定的差距, 有待深入研究
 

Abstract

The status of Taxus resources and taxol production w as introduced .In China , Taxus includes 4 species and 1 variety , e.g . Taxus cuspidata Sieb .et Zucc., T . y unnanensis Cheng et L .K .Fu , T .wallichiana Zucc., T .chinensis (Pilger) Rehd .and T .chinensis var. mairei (Lemee et Lévl .)Cheng et L .K .Fu .Their distributions centralize in the northeast , southwest and east area in China , especially in Yunnan Province .There are about 1 350 000 of Taxus trees in the west region of Heng Duan mountain in the west Yunnan .But the wild resources are destroy ed seriously. Therefore, the protection and artificial cultivation of the wild resources are necessary. Taxol is a new antitumor compound which exhibits the remarkable potential for the treatment of breast and ovarian cancers .Taxol production is presently an important research field because of its low content and structural complexity , the extraction from other parts of the plants besides bark , the artificial cultivation , chemical synthesis , the research on taxol deriv ative and biotechnology have been studied .In China , some results in taxol production have been obtained , but more works should be done in the future.
 

关键词红豆杉; 资源; 紫杉醇
Key wordsT axus L .; plant resources; taxol
作者刘 涤 ,章国瑛 ,王 晓 ,胡之璧
所在单位上海中医药大学, 上海 200032
点击量683
下载次数463
基金项目国家中医药管理局和上海市教委科研基金