2021年10月17日 星期日
枇杷叶中三萜酸类成分抗糖尿病及其并发症的体外活性研究
Study on in vitro activities of triterpene acids from leaf of Eriobotrya japonica against diabetes and its complications
2020年 第29卷 第3期 页码[78-80]    下载全文[29.9MB]  
Abstract

 In vitro inhibitory effects of six triterpene acids (including euscaphic acid, tormentic acid, corosolic acid, maslinic acid, oleanolic acid, and ursolic acid) from leaf of Eriobotrya japonica (Thunb.) Lindl. on α-glucosidase activity and production of nonenzymatic glycosylation products Amadori and AGEs were studied. The results show that the six triterpene acids have strong inhibitory effects on α-glucosidase activity, with semi-inhibitory concentration (IC50) of 0.76-35.45 μg·mL-1, in which, ursolic acid has the strongest inhibitory effect. The six triterpene acids show inhibitory effects on Amadori formation, and the inhibitory effects decrease significantly with the decrease of mass concentration, in which, 50 μg·mL-1 euscaphic acid has the strongest inhibitory effect, with inhibition rate of 83.63%; however, the six triterpene acids have no evident inhibitory effect on AGEs formation, and the inhibition rate of 50 μg·mL-1 euscaphic acid has the strongest inhibitory effect, but the inhibition rate is only 18.71%. In conclusion, triterpene acids from leaf of E. japonica have potential therapeutic effects on diabetes and its complications.

关键词枇杷叶; 三萜酸类成分; α-葡萄糖苷酶; 非酶糖化反应产物
Key wordsleaf of Eriobotrya japonica (Thunb.) Lindl.; triterpene acids; αglucosidase; nonenzymatic glycation product
作者陈剑, 吴月娴, 吕寒, 简暾昱, 丁晓琴, 李佳伟, 刘艳, 任冰如
所在单位江苏省中国科学院植物研究所(南京中山植物园) 江苏省抗糖尿病药物筛选技术服务中心, 江苏 南京 210014
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基金项目国家自然科学基金资助项目(81773885; 81703224)