2021年12月6日 星期一
单叶蔓荆果实中多甲氧基黄酮类成分的分离、鉴定及细胞毒活性分析
Isolation, identification and cytotoxic activity analysis of polymethoxylated flavonoids from Vitex rotundifolia fruit
2015年 第24卷 第2期 页码[118-120]    下载全文[0.7MB]  
Abstract

Six polymethoxylated flavonoids were isolated from ethyl acetate fraction of ethanol extracts from Vitex rotundifolia Linn. f. fruit, and their structures were identified by NMR and MS methods, and cytotoxic activity of six compounds are analyzed by MTT method. The six compounds are oroxylin A (1), chrysosplenol-D (2), casticin (3),artemetin (4), persicogenin (5) and 5,3’-dihydroxy-6,7,4’-trimethoxyflavanone (6). In which, persicogenin is isolated from V. rotundifolia for the first time. Oroxylin A, casticin, artemetin and 5,3’- dihydroxy- 6,7,4’ –trimethoxyflavanone can inhibit proliferation of human liver cancer cell line HepG2 in vitro, and their IC50 is 11. 90, 12. 54, 13. 69 and 11. 76 μmol·L-1, respectively, showing that the four compounds have a certain cytotoxic activity.

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关键词单叶蔓荆; 果实; 多甲氧基黄酮类; 人肝癌细胞株HepG2; 细胞毒活性
Key wordsVitex rotundifolia Linn. f.; fruit; polymethoxylated flavonoids; human liver cancer cell line HepG2; cytotoxic activity
作者高雪a,b,c, 陈刚a,b,c
所在单位重庆工商大学: a. 催化与功能有机分子重庆市重点实验室, b. 天然药物研究重庆高校市级重点实验室,c. 环境与生物工程学院, 重庆400067
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基金项目重庆市高校创新团队建设计划项目(KJTO201314)