对细叶石斛(Dendrobium hancockii Rofle)茎上部、茎中部、茎下部和根中的多糖、生物碱和矿质元素含量进行了分析,并研究了其水溶性提取物对SD大鼠胸主动脉血管的舒张效应。结果表明,细叶石斛中总多糖含量较高,并含有较多的钾、钙、镁、铁、锰、锶、钛和铜等元素,与细茎石斛〔D. moniliforme (L.)Sw.〕及铁皮石斛(D. officinale Kimura et Migo)相比,其水溶性多糖和生物碱的含量较低,而且不同部位中的含量存在差异。细叶石斛水溶性提取物强烈拮抗苯肾上腺素所致的大鼠胸主动脉血管收缩作用,对内皮完整和无内皮功能的2种样本均引起类似的浓度依赖性舒张效应,相关系数有显著意义(>r0.01),两者的IC₅₀分别为0.309和0.404g /L。

Contents of alkaloids, polysaccharides and mineral elements in different parts of Dendrobium hancockii Rofle and relaxed effects of its water-soluble extraction on isolated aortic rings of SD rats were researched. The experiment results showed that the medicinal plant D . hancockii has higher contents of total polysaccharides and mineral elements, while has relatively low in contents of alkaloids and water-soluble polysaccharides compared with Xijing Shi-hu 〔D. moniliforme ( L. )Sw . 〕 and Tiepi Shi-hu ( D. officinale Kimura et Migo).Distributions of these ingredients in upper, middle, lower stem and root parts in D. hancockii were unequal. The water-soluble extraction of D. hancockii evoked analogous concentration dependent relaxation on isolated aortic rings of SD rat with and without endothelium. The pharmacodynamic parameters indicated that the half inhibit concentration ( IC₅₀)were about 0. 309 and 0. 404 g/L respectively.