从枸骨中分离了20个化合物,对其中的3个进行了心血管方面的药理作用研究。结果表明,3,4-二羟基桂皮酸和胡萝卜甙对小鼠缺氧、氯仿诱发的小鼠心室纤颤及脑垂体后叶素诱发的大鼠心肌缺血均无保护作用,也不能改变豚鼠离体心肌的心率、冠脉流量及心肌收缩力。3-β –O- (β-D-吡喃葡萄糖基)-α-L-吡喃阿拉伯糖基坡摸酸 β-28-O-D-吡喃葡萄糖酯(命名为枸骨甙4)对小鼠缺氧、氯仿诱发的小鼠心室纤颤无保护作用,对脑垂体后叶素诱发的心肌缺血有一定的保护作用,不改变豚鼠离体心肌的心率和冠脉流量,但可显著降低心肌收缩力。

Twenty compounds were isolated from Ilex cornuta Lindl .ex Paxt .Pharmacological tests of 3 compounds for angiocardiopathy gave the following results :3, 4-dihydroxycinnamunic acid and daucostorol did not show the action to protect mice against hypoxia, ventricular fibrillation resulted by chloroform. and pituitrin resulted by myocardial ischemia, and the action to influence heart rate of apo-cardiac muscle, coronary blood flow and cardiac contractility of guinea pigs .3-β-O-( β-D-glucopyranosyl)-α-L-arabinopyranosyl-pomolic acid (28 →1)-β-O-D-glucopyranosyl ester ( named gouguside 4) did not show the action to protect mice against hypoxia, ventricular fibrillation resulted by chloroform, but showed the effect to protect mice against pituitrin resulted by myocardial ischemia.Gouguside 4 can not influence heart rate of apo-cardiac muscle and coronary blood flow, but can markedly decrease cardiac contractility of guinea pigs .