2018年12月16日 星期日
白菊木树皮和枝叶甲醇提取物及化学成分的体外抗炎活性研究
Study on in vitro antiinflammatory activities of methanol extracts from barks, branches and leaves and chemical constituent of Gochnatia decora
2018年 第27卷 第4期 页码[101-103]
Abstract

Effects of methanol extracts from barks, branches and leaves and 15β-hydroxy-ent-16-kaur-19-oic-β-D-glucopyranosyl ester (Gd-1) of Gochnatia decora (Kurz) A. L. Cabrera on viability of mouse RAW264.7 macrophages and production of NO, reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in mouse RAW264.7 macrophages were studied by using the model of lipopolysaccharide (LPS)induced mouse RAW264.7 macrophages. The results show that 0.39, 1.56, 6.25, 25 and 100 μg·mL-1 methanol extracts from barks, branches and leaves, and 0.39, 1.56, 6.25, 25 and 100 μmol·L-1 Gd-1 of G. decora have no obvious effect on growth of mouse RAW264.7 macrophages; compared with the model control group, methanol extracts from barks, branches and leaves and Gd-1 of G. decora can inhibit NO and ROS production, and high dosage group has significant effects on TNF-α and IL-6. It is suggested that methanol extracts from barks, branches and leaves and Gd-1 of G. decora all have some anti-inflammatory activities, and Gd-1 can serve as a target product for further isolation, purification, and activity study.
 

关键词白菊木; 抗炎活性; 活性氧(ROS); 肿瘤坏死因子-α(TNF-α); 白细胞介素-6(IL-6)
Key wordsGochnatia decora (Kurz) A. L. Cabrera; anti-inflammatory activity; reactive oxygen species (ROS); tumor necrosis factor-α (TNF-α); interleukin-6 (IL-6)
作者刘兰, 刘燕芳, 李宝才, 张敉
所在单位昆明理工大学生命科学与技术学院, 云南 昆明 650500
点击量55
基金项目国家自然科学基金资助项目(31500287)