2018年12月16日 星期日
不同类型枇杷叶三萜酸类成分含量及降糖活性的比较
Comparisons on contents of triterpenoid acid components and hypoglycemic activity in different types of Eriobotrya japonica leaves
2017年 第26卷 第4期 页码[101-103]    下载全文[0.9MB]  
Abstract

To select Chinese medicine Eriobotrya japonica (Thunb.) Lindl. leaves with high hypoglycemic activity, contents of total ashes, extracts and triterpenoid acid components in crude and processed products of mature leaves and fallen leaves of E. japonica from Xishan Island in Suzhou of Jiangsu in November were compared, and their ability to inhibit α-glucosidase activity was also compared. The results show that contents of total ashes and extracts in different types of E. japonica leaves are in accord with related criteria. Contents of each triterpenoid acid component in fallen leaves are significantly higher than those in mature leaves in general, and total contents of triterpenoid acid components in crude and processed products of mature leaves, and crude and processed products of fallen leaves are 1.671 0%, 1.690 0%, 3.774 1%, and 2.717 5%, respectively. α-glucosidase inhibitory activity of different types of E. japonica leaves is significantly higher than that of acarbose, in which, half-inhibitory concentration (IC50) of crude product of fallen leaves is the lowest with only 64.170 μg·mL-1. In conclusion, fallen leaves are the optimum choice for taking E. japonica leaves as hypoglycemic Chinese medicine.

关键词枇杷叶; 成熟叶; 落叶; HPLC-ELSD; 三萜酸类成分; α-葡萄糖苷酶
Key wordsEriobotrya japonica (Thunb.) Lindl. leaf; mature leaf; fallen leaf; HPLC-ELSD; triterpenoid acid component; α-glucosidase
作者吴月娴, 吕寒, 简暾昱, 陈剑, 马丽, 任冰如, 李维林
所在单位江苏省中国科学院植物研究所(南京中山植物园) 江苏省抗糖尿病药物筛选技术服务中心, 江苏 南京 210014
点击量530
基金项目江苏省重点研发计划-社会发展面上项目(BE2015690); 江苏省科技基础设施建设计划-科技公共服务平台项目(BM2011117)