2022年11月28日 星期一
北沙参中佛手柑内酯的分离鉴定及体外抗肿瘤活性的初步测定
Isolation and identification of bergapten in dry root of Glehnia littoralis and preliminary determination of its antitumor activity in vitro
2010年 第19卷 第1期 页码[95-96]    下载全文[0.3MB]  
Abstract

Using silica gel column chromatography and recrystallization, a light yellow needle crystal with a purity of 97.21% was obtained from ethyl acetate fraction of ethanol extract from dry root of Glehnia littoralis Fr.Schmidt ex Miq.,and was identified as bergapten by means of NMR. The experimental result of antitumor activity in vitro shows that 0.01-100.00 mg·L-1 bergapten have inhibitory effect to liver cancer cell line HEP-G2, in which inhibition of 100.00 mg·L-1 bergapten is the highest with an inhibitory rate of 95.0%. In concentrations of 0.01-100.00 mg·L-1,only 100.00 mg·L-1 bergapten has an inhibitory effect to stomach cancer cell line SGC-7901 with an inhibitory rate of 79.6%. 

关键词北沙参; 佛手柑内酯; 分离鉴定; 抗肿瘤活性
Key wordsGlehnia littoralis Fr. Schmidt ex Miq.; bergapten; isolation and identification; antitumor activity
作者董 芳,刘汉柱,孙 阳,辛 华
所在单位青岛农业大学,山东青岛266109
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基金项目山东省自然科学基金资助项目(Y 2008D 45)