2021年4月23日 星期五
镰叶西番莲地上部分水提取物对乙醇诱导小鼠急性肝损伤的保护作用研究
Study on protective effect of water extract from above-ground part of Passiflora wilsonii on ethanol-induced acute liver injury in mice
2020年 第29卷 第1期 页码[72-74]    下载全文[6.9MB]  
Abstract

 Liver protective effect of water extract from aboveground part of Passiflora wilsonii Hemsl. (WEPW) on ethanol-induced acute liver injury in mice was evaluated. The results show that compared with normal group, alanine aminotransferase activity and contents of triglyceride, total cholesterol and very low-density lipoprotein in serum, liver index, and contents of triglyceride and malondialdehyde in liver tissue of mice in ethanol-induced acute liver injury group (giving volume fraction of 50% ethanol at dose of 12 mL·kg-1·d-1 by gavage) increase significantly or obviously significantly. Compared with ethanol-induced acute liver injury group, alanine aminotransferase activity and triglyceride content in serum, liver index, and contents of triglyceride and malondialdehyde in liver tissue of mice given WEPW at doses of 100, 200, and 400 mg·kg-1·d-1 by gavage decrease obviously, and there is a concentration-dependent relationship. WEPW can obviously ameliorate liver accumulation of lipid droplets of mice with ethanol-induced acute liver injury by histopathological section of liver. It is suggested that WEPW has obvious preventive and protective effects on ethanol-induced acute liver injury in 

mice.

关键词镰叶西番莲地上部分; 急性肝损伤; 护肝
Key wordsabove-ground part of Passiflora wilsonii Hemsl.; acute liver injury; liver protection
作者卢传礼1,2
所在单位1. 广东省生物工程研究所(广州甘蔗糖业研究所), 广东 广州 510316; 2. 中国科学院西双版纳热带植物园, 云南 西双版纳 666303
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基金项目国家自然科学基金资助项目(81602991); 中国科学院“西部之光”项目; 广东省科学院项目(2019GDASYL-0103039)