Contents of ten representative phenolics （including six caffeoylquinic acids of neochlorogenic acid， chlorogenic acid， cryptochlorogenic acid， 3，4dicaffeoylquinic acid， 3，5dicaffeoylquinic acid and 4，5dicaffeoylquinic acid and four flavonoids of rutin， isoquercitrin， nicotiflorin and astragalin） in leaves of Gynura divaricata （Linn.） DC. from April to November were assayed by using HPLC method. The results show that there are evident variations in total contents of caffeoylquinic acids and flavonoids in leaves of G. divaricata in different months， in which， total contents of caffeoylquinic acids and flavonoids both have two peak values in April and August. In the same month， total content of flavonoids is higher than that of caffeoylquinic acids in leaves of G. divaricata. Contents of total phenolics in leaves of G. divaricata are relatively high in April and August， which are 3.317 2 and 2.716 0 mg·g-1 respectively， and are significantly higher than those in other months. Combined with yield， August is considered as the best harvest period of G. divaricata.